MYC-regulated Mevalonate Metabolism Maintains Brain Tumor Initiating Cells

Metabolic dysregulation drives tumor initiation in a subset of glioblastomas harboring isocitrate dehydrogenase (IDH) mutations, but metabolic alterations in glioblastomas with wildtype IDH are poorly understood. MYC promotes metabolic reprogramming in cancer, but targeting MYC has proven notoriousl...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Wang, Xiuxing, Huang, Zhi, Wu, Qiulian, Prager, Briana C., Mack, Stephen C., Yang, Kailin, Kim, Leo J.Y., Gimple, Ryan C., Shi, Yu, Lai, Sisi, Xie, Qi, Miller, Tyler E., Hubert, Christopher G., Song, Anne, Dong, Zhen, Zhou, Wenchao, Fang, Xiaoguang, Zhu, Zhe, Mahadev, Vaidehi, Bao, Shideng, Rich, Jeremy N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600855/
https://ncbi.nlm.nih.gov/pubmed/28729418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0114
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