MYC-regulated Mevalonate Metabolism Maintains Brain Tumor Initiating Cells

Metabolic dysregulation drives tumor initiation in a subset of glioblastomas harboring isocitrate dehydrogenase (IDH) mutations, but metabolic alterations in glioblastomas with wildtype IDH are poorly understood. MYC promotes metabolic reprogramming in cancer, but targeting MYC has proven notoriousl...

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Publicado en:Cancer Res
Main Authors: Wang, Xiuxing, Huang, Zhi, Wu, Qiulian, Prager, Briana C., Mack, Stephen C., Yang, Kailin, Kim, Leo J.Y., Gimple, Ryan C., Shi, Yu, Lai, Sisi, Xie, Qi, Miller, Tyler E., Hubert, Christopher G., Song, Anne, Dong, Zhen, Zhou, Wenchao, Fang, Xiaoguang, Zhu, Zhe, Mahadev, Vaidehi, Bao, Shideng, Rich, Jeremy N.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600855/
https://ncbi.nlm.nih.gov/pubmed/28729418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0114
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