RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation

Glioblastomas co-opt stem cell regulatory pathways to maintain brain tumor–initiating cells (BTICs), also known as cancer stem cells. NOTCH signaling has been a molecular target in BTICs, but NOTCH antagonists have demonstrated limited efficacy in clinical trials. Recombining binding protein suppres...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Xie, Qi, Wu, Qiulian, Kim, Leo, Miller, Tyler E., Liau, Brian B., Mack, Stephen C., Yang, Kailin, Factor, Daniel C., Fang, Xiaoguang, Huang, Zhi, Zhou, Wenchao, Alazem, Kareem, Wang, Xiuxing, Bernstein, Bradley E., Bao, Shideng, Rich, Jeremy N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922685/
https://ncbi.nlm.nih.gov/pubmed/27322055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86114
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