RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation

Glioblastomas co-opt stem cell regulatory pathways to maintain brain tumor–initiating cells (BTICs), also known as cancer stem cells. NOTCH signaling has been a molecular target in BTICs, but NOTCH antagonists have demonstrated limited efficacy in clinical trials. Recombining binding protein suppres...

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發表在:J Clin Invest
Main Authors: Xie, Qi, Wu, Qiulian, Kim, Leo, Miller, Tyler E., Liau, Brian B., Mack, Stephen C., Yang, Kailin, Factor, Daniel C., Fang, Xiaoguang, Huang, Zhi, Zhou, Wenchao, Alazem, Kareem, Wang, Xiuxing, Bernstein, Bradley E., Bao, Shideng, Rich, Jeremy N.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922685/
https://ncbi.nlm.nih.gov/pubmed/27322055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86114
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