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Deubiquitinase HAUSP Stabilizes REST and Promotes Maintenance of Neural Progenitor Cells
The repressor element 1-silencing transcription factor (REST) functions as a master regulator to maintain neural stem/progenitor cells (NPCs). REST undergoes proteasomal degradation through β-TrCP-mediated ubiquitination during neuronal differentiation. However, reciprocal mechanisms that stabilize...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076066/ https://ncbi.nlm.nih.gov/pubmed/21258371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2153 |
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