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L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1

Glioblastomas (GBMs) are highly lethal brain tumours with current therapies limited to palliation due to therapeutic resistance. We previously demonstrated that GBM stem cells (GSCs) display a preferential activation of DNA damage checkpoint and are relatively resistant to radiation. However, the mo...

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Main Authors: Cheng, Lin, Wu, Qiulian, Huang, Zhi, Guryanova, Olga A, Huang, Qian, Shou, Weinian, Rich, Jeremy N, Bao, Shideng
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049209/
https://ncbi.nlm.nih.gov/pubmed/21297581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.10
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