Deubiquitinase HAUSP Stabilizes REST and Promotes Maintenance of Neural Progenitor Cells

The repressor element 1-silencing transcription factor (REST) functions as a master regulator to maintain neural stem/progenitor cells (NPCs). REST undergoes proteasomal degradation through β-TrCP-mediated ubiquitination during neuronal differentiation. However, reciprocal mechanisms that stabilize...

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Bibliografiske detaljer
Main Authors: Huang, Zhi, Wu, Qiulian, Guryanova, Olga A., Cheng, Lin, Shou, Weinian, Rich, Jeremy N., Bao, Shideng
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076066/
https://ncbi.nlm.nih.gov/pubmed/21258371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2153
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