Endothelin-1–Rho kinase interactions impair lung structure and cause pulmonary hypertension after bleomycin exposure in neonatal rat pups

Bronchopulmonary dysplasia (BPD) is the chronic lung disease associated with premature birth, characterized by impaired vascular and alveolar growth. In neonatal rats bleomycin decreases lung growth and causes pulmonary hypertension (PH), which is poorly responsive to nitric oxide. In the developing...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Gien, Jason, Tseng, Nancy, Seedorf, Gregory, Kuhn, Katherine, Abman, Steven H.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206397/
https://ncbi.nlm.nih.gov/pubmed/27760762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00066.2016
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