Endothelin-1 Impairs Angiogenesis Through Rho-kinase Activation after Chronic Intrauterine Pulmonary Hypertension in Fetal Sheep

BACKGROUND: Endothelin-1 (ET-1) and rho-kinase (ROCK) increase vascular tone in experimental PPHN but whether ET-1 activates ROCK to decrease angiogenesis in the developing lung remains unknown. METHODS: Proximal PAEC were harvested from fetal sheep after partial ligation of the ductus arteriosus in...

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Main Authors: Gien, Jason, Tseng, Nancy, Seedorf, Gregory, Roe, Gates, Abman, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767851/
https://ncbi.nlm.nih.gov/pubmed/23202724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2012.177
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