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Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro

Persistent pulmonary hypertension of the newborn (PPHN) is characterized by endothelial dysfunction and decreased vascular growth. The role of Rho kinase activity in modulating endothelial function and regulating angiogenesis during normal lung development and in PPHN is unknown. We hypothesized tha...

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Detalhes bibliográficos
Main Authors: Gien, Jason, Seedorf, Gregory J., Balasubramaniam, Vivek, Tseng, Nancy, Markham, Neil, Abman, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575951/
https://ncbi.nlm.nih.gov/pubmed/18621906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00516.2007
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