Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro

Persistent pulmonary hypertension of the newborn (PPHN) is characterized by endothelial dysfunction and decreased vascular growth. The role of Rho kinase activity in modulating endothelial function and regulating angiogenesis during normal lung development and in PPHN is unknown. We hypothesized tha...

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Autori principali: Gien, Jason, Seedorf, Gregory J., Balasubramaniam, Vivek, Tseng, Nancy, Markham, Neil, Abman, Steven H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575951/
https://ncbi.nlm.nih.gov/pubmed/18621906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00516.2007
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