Endothelin-1 decreases endothelial PPARγ signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension

Increased endothelin-1 (ET-1) disrupts angiogenesis in persistent pulmonary hypertension of the newborn (PPHN), but pathogenic mechanisms are unclear. Peroxisome proliferator activated receptor γ (PPARγ) is decreased in adult pulmonary hypertension, but whether ET-1-PPARγ interactions impair endothe...

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Detalhes bibliográficos
Main Authors: Wolf, David, Tseng, Nancy, Seedorf, Gregory, Roe, Gates, Abman, Steven H., Gien, Jason
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920227/
https://ncbi.nlm.nih.gov/pubmed/24337925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00277.2013
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