Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro

Persistent pulmonary hypertension of the newborn (PPHN) is characterized by endothelial dysfunction and decreased vascular growth. The role of Rho kinase activity in modulating endothelial function and regulating angiogenesis during normal lung development and in PPHN is unknown. We hypothesized tha...

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Autors principals: Gien, Jason, Seedorf, Gregory J., Balasubramaniam, Vivek, Tseng, Nancy, Markham, Neil, Abman, Steven H.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575951/
https://ncbi.nlm.nih.gov/pubmed/18621906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00516.2007
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