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Endothelin-1 Impairs Angiogenesis Through Rho-kinase Activation after Chronic Intrauterine Pulmonary Hypertension in Fetal Sheep
BACKGROUND: Endothelin-1 (ET-1) and rho-kinase (ROCK) increase vascular tone in experimental PPHN but whether ET-1 activates ROCK to decrease angiogenesis in the developing lung remains unknown. METHODS: Proximal PAEC were harvested from fetal sheep after partial ligation of the ductus arteriosus in...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3767851/ https://ncbi.nlm.nih.gov/pubmed/23202724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2012.177 |
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