Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension

Although inhaled NO (iNO) therapy is often effective in treating infants with persistent pulmonary hypertension of the newborn (PPHN), up to 40% of patients fail to respond, which may be partly due to abnormal expression and function of soluble guanylate cyclase (sGC). To determine whether altered s...

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Main Authors: Chester, Marc, Seedorf, Gregory, Tourneux, Pierre, Gien, Jason, Tseng, Nancy, Grover, Theresa, Wright, Jason, Stasch, Johannes-Peter, Abman, Steven H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2011
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213988/
https://ncbi.nlm.nih.gov/pubmed/21856817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00138.2010
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