Inhaled Agonists of Soluble Guanylate Cyclase Induce Selective Pulmonary Vasodilation

Rationale: Nitric oxide–independent agonists of soluble guanylate cyclase (sGC) have been developed. Objectives: We tested whether inhalation of novel dry-powder microparticle formulations containing sGC stimulators (BAY 41-2272, BAY 41-8543) or an sGC activator (BAY 58-2667) would produce selective...

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Detalhes bibliográficos
Main Authors: Evgenov, Oleg V., Kohane, Daniel S., Bloch, Kenneth D., Stasch, Johannes-Peter, Volpato, Gian P., Bellas, Evangelia, Evgenov, Natalia V., Buys, Emmanuel S., Gnoth, Mark J., Graveline, Amanda R., Liu, Rong, Hess, Dean R., Langer, Robert, Zapol, Warren M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2007
Assuntos:
H. Pulmonary Vascular Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2176100/
https://ncbi.nlm.nih.gov/pubmed/17872487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200707-1121OC
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