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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). Impaired bioavailability and/or responsiveness to endogenous NO has been implicated in the pathogenesis of cardiovascular and other diseases. Current therapies that involve the use of organic nitrates...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2225477/ https://ncbi.nlm.nih.gov/pubmed/16955067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd2038 |
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