Fluorescence Dequenching Makes Haem-Free Soluble Guanylate Cyclase Detectable in Living Cells

In cardiovascular disease, the protective NO/sGC/cGMP signalling-pathway is impaired due to a decreased pool of NO-sensitive haem-containing sGC accompanied by a reciprocal increase in NO-insensitive haem-free sGC. However, no direct method to detect cellular haem-free sGC other than its activation...

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Autori principali: Hoffmann, Linda S., Schmidt, Peter M., Keim, Yvonne, Hoffmann, Carsten, Schmidt, Harald H. H. W., Stasch, Johannes-Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157391/
https://ncbi.nlm.nih.gov/pubmed/21858179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023596
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