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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). Impaired bioavailability and/or responsiveness to endogenous NO has been implicated in the pathogenesis of cardiovascular and other diseases. Current therapies that involve the use of organic nitrates...

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Détails bibliographiques
Auteurs principaux: Evgenov, Oleg V., Pacher, Pál, Schmidt, Peter M., Haskó, György, Schmidt, Harald H. H. W., Stasch, Johannes-Peter
Format: Artigo
Langue:Inglês
Publié: 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225477/
https://ncbi.nlm.nih.gov/pubmed/16955067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd2038
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