Targeting integrin α(5)β(1) ameliorates severe airway hyperresponsiveness in experimental asthma

Treatment options are limited for severe asthma, and the need for additional therapies remains great. Previously, we demonstrated that integrin α(v)β(6)-deficient mice are protected from airway hyperresponsiveness, due in part to increased expression of the murine ortholog of human chymase. Here, we...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Sundaram, Aparna, Chen, Chun, Khalifeh-Soltani, Amin, Atakilit, Amha, Ren, Xin, Qiu, Wenli, Jo, Hyunil, DeGrado, William, Huang, Xiaozhu, Sheppard, Dean
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199700/
https://ncbi.nlm.nih.gov/pubmed/27918306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88555
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