Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer

Previous studies have associated the overexpression of histone deacetylase 2 (HDAC2) and the presence of TP53 mutations with the progression to advanced stage drug resistant colorectal cancer (CRC). However, the mechanistic link between HDAC2 expression and the TP53 mutational status has remained un...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Alzoubi, Samer, Brody, Leigh, Rahman, Sunniyat, Mahul-Mellier, Anne-Laure, Mercado, Nicolas, Ito, Kazuhiro, El-Bahrawy, Mona, Silver, Andrew, Boobis, Alan, Bell, Jimmy D., Hajji, Nabil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190114/
https://ncbi.nlm.nih.gov/pubmed/27283986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9887
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