Passive Smoking Impairs Histone Deacetylase-2 in Children With Severe Asthma

BACKGROUND: Parental smoking is known to worsen asthma symptoms in children and to make them refractory to asthma treatment, but the molecular mechanism is unclear. Oxidative stress from tobacco smoke has been reported to impair histone deacetylase-2 (HDAC2) via phosphoinositide-3-kinase (PI3K)/Akt...

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Autores principales: Kobayashi, Yoshiki, Bossley, Cara, Gupta, Atul, Akashi, Kenichi, Tsartsali, Lemonia, Mercado, Nicolas, Barnes, Peter J., Bush, Andrew, Ito, Kazuhiro
Formato: Artigo
Lenguaje:Inglês
Publicado: American College of Chest Physicians 2014
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913299/
https://ncbi.nlm.nih.gov/pubmed/24030221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.13-0835
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