Passive Smoking Impairs Histone Deacetylase-2 in Children With Severe Asthma

BACKGROUND: Parental smoking is known to worsen asthma symptoms in children and to make them refractory to asthma treatment, but the molecular mechanism is unclear. Oxidative stress from tobacco smoke has been reported to impair histone deacetylase-2 (HDAC2) via phosphoinositide-3-kinase (PI3K)/Akt...

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Bibliographic Details
Main Authors: Kobayashi, Yoshiki, Bossley, Cara, Gupta, Atul, Akashi, Kenichi, Tsartsali, Lemonia, Mercado, Nicolas, Barnes, Peter J., Bush, Andrew, Ito, Kazuhiro
Format: Artigo
Language:Inglês
Published: American College of Chest Physicians 2014
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913299/
https://ncbi.nlm.nih.gov/pubmed/24030221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.13-0835
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