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Defects of Protein Phosphatase 2A Causes Corticosteroid Insensitivity in Severe Asthma

BACKGROUND: Corticosteroid insensitivity is a major barrier of treatment for some chronic inflammatory diseases, such as severe asthma, but the molecular mechanism of the insensitivity has not been fully elucidated. The object of this study is to investigate the role of protein phosphate 2A (PP2A),...

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Détails bibliographiques
Auteurs principaux: Kobayashi, Yoshiki, Mercado, Nicolas, Barnes, Peter J., Ito, Kazuhiro
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242752/
https://ncbi.nlm.nih.gov/pubmed/22205926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027627
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