Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity

BACKGROUND: We have recently reported that protein phosphate 2A (PP2A) inactivation resulted in increased phosphorylation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase 1 (JNK1) and glucocorticoid receptors (GR) at Ser(226), thereby reducing GR nuclear translocation and causi...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Kobayashi, Yoshiki, Ito, Kazuhiro, Kanda, Akira, Tomoda, Koich, Miller-Larsson, Anna, Barnes, Peter J., Mercado, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806463/
https://ncbi.nlm.nih.gov/pubmed/27013170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0349-0
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