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Passive Smoking Impairs Histone Deacetylase-2 in Children With Severe Asthma
BACKGROUND: Parental smoking is known to worsen asthma symptoms in children and to make them refractory to asthma treatment, but the molecular mechanism is unclear. Oxidative stress from tobacco smoke has been reported to impair histone deacetylase-2 (HDAC2) via phosphoinositide-3-kinase (PI3K)/Akt...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American College of Chest Physicians
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3913299/ https://ncbi.nlm.nih.gov/pubmed/24030221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.13-0835 |
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