Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines

BACKGROUND: The pathology of pediatric severe therapy-resistant asthma (STRA) is little understood. OBJECTIVES: We hypothesized that STRA in children is characterized by airway eosinophilia and mast cell inflammation and is driven by the T(H)2 cytokines IL-4, IL-5, and IL-13. METHODS: Sixty-nine chi...

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Main Authors: Bossley, Cara J., Fleming, Louise, Gupta, Atul, Regamey, Nicolas, Frith, Jennifer, Oates, Timothy, Tsartsali, Lemonia, Lloyd, Clare M., Bush, Andrew, Saglani, Sejal
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381727/
https://ncbi.nlm.nih.gov/pubmed/22385633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2012.01.059
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