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Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

BACKGROUND: Granulocytes are important in the pathogenesis of several inflammatory diseases. Apoptosis is pivotal in the resolution of inflammation. Apoptosis in malignant cells is induced by histone deacetylase (HDAC) inhibitors, whereas HDAC inhibitors do not usually induce apoptosis in non-malign...

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Detalhes bibliográficos
Main Authors: Kankaanranta, Hannu, Janka-Junttila, Mirkka, Ilmarinen-Salo, Pinja, Ito, Kazuhiro, Jalonen, Ulla, Ito, Misako, Adcock, Ian M, Moilanen, Eeva, Zhang, Xianzhi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841159/
https://ncbi.nlm.nih.gov/pubmed/20181093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-7-9
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