Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

BACKGROUND: Granulocytes are important in the pathogenesis of several inflammatory diseases. Apoptosis is pivotal in the resolution of inflammation. Apoptosis in malignant cells is induced by histone deacetylase (HDAC) inhibitors, whereas HDAC inhibitors do not usually induce apoptosis in non-malign...

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Bibliographische Detailangaben
Hauptverfasser: Kankaanranta, Hannu, Janka-Junttila, Mirkka, Ilmarinen-Salo, Pinja, Ito, Kazuhiro, Jalonen, Ulla, Ito, Misako, Adcock, Ian M, Moilanen, Eeva, Zhang, Xianzhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841159/
https://ncbi.nlm.nih.gov/pubmed/20181093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-7-9
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