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Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

Genetic defects in DNA repair mechanisms and cell cycle checkpoint (CCC) genes result in increased genomic instability and cancer predisposition. Discovery of mammalian homologs of yeast CCC genes suggests conservation of checkpoint mechanisms between yeast and mammals. However, the role of many CCC...

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Publicat a:EMBO J
Autors principals: Budzowska, Magda, Jaspers, Iris, Essers, Jeroen, de Waard, Harm, van Drunen, Ellen, Hanada, Katsuhiro, Beverloo, Berna, Hendriks, Rudolf W, de Klein, Annelies, Kanaar, Roland, Hoeijmakers, Jan H, Maas, Alex
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2004
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516625/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15297881/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600353
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