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Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

Genetic defects in DNA repair mechanisms and cell cycle checkpoint (CCC) genes result in increased genomic instability and cancer predisposition. Discovery of mammalian homologs of yeast CCC genes suggests conservation of checkpoint mechanisms between yeast and mammals. However, the role of many CCC...

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Publicado no:EMBO J
Principais autores: Budzowska, Magda, Jaspers, Iris, Essers, Jeroen, de Waard, Harm, van Drunen, Ellen, Hanada, Katsuhiro, Beverloo, Berna, Hendriks, Rudolf W, de Klein, Annelies, Kanaar, Roland, Hoeijmakers, Jan H, Maas, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516625/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15297881/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600353
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