Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

Genetic defects in DNA repair mechanisms and cell cycle checkpoint (CCC) genes result in increased genomic instability and cancer predisposition. Discovery of mammalian homologs of yeast CCC genes suggests conservation of checkpoint mechanisms between yeast and mammals. However, the role of many CCC...

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Pubblicato in:	EMBO J
Autori principali:	Budzowska, Magda, Jaspers, Iris, Essers, Jeroen, de Waard, Harm, van Drunen, Ellen, Hanada, Katsuhiro, Beverloo, Berna, Hendriks, Rudolf W, de Klein, Annelies, Kanaar, Roland, Hoeijmakers, Jan H, Maas, Alex
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2004
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15297881/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600353
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