Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

Genetic defects in DNA repair mechanisms and cell cycle checkpoint (CCC) genes result in increased genomic instability and cancer predisposition. Discovery of mammalian homologs of yeast CCC genes suggests conservation of checkpoint mechanisms between yeast and mammals. However, the role of many CCC...

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Detalhes bibliográficos
Main Authors: Budzowska, Magda, Jaspers, Iris, Essers, Jeroen, de Waard, Harm, van Drunen, Ellen, Hanada, Katsuhiro, Beverloo, Berna, Hendriks, Rudolf W, de Klein, Annelies, Kanaar, Roland, Hoeijmakers, Jan H, Maas, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC516625/
https://ncbi.nlm.nih.gov/pubmed/15297881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600353
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