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Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

Genetic defects in DNA repair mechanisms and cell cycle checkpoint (CCC) genes result in increased genomic instability and cancer predisposition. Discovery of mammalian homologs of yeast CCC genes suggests conservation of checkpoint mechanisms between yeast and mammals. However, the role of many CCC...

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Izdano u:EMBO J
Glavni autori: Budzowska, Magda, Jaspers, Iris, Essers, Jeroen, de Waard, Harm, van Drunen, Ellen, Hanada, Katsuhiro, Beverloo, Berna, Hendriks, Rudolf W, de Klein, Annelies, Kanaar, Roland, Hoeijmakers, Jan H, Maas, Alex
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2004
Teme:
Article
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516625/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15297881/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600353
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