The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks

Interstrand cross-links (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer chemotherapy. ICLs covalently tether both strands of duplex DNA, preventing the strand unwinding that is essential for polymerase access. The mechanism of ICL repair in mammalian cel...

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Autors principals: Niedernhofer, Laura J., Odijk, Hanny, Budzowska, Magda, van Drunen, Ellen, Maas, Alex, Theil, Arjan F., de Wit, Jan, Jaspers, N. G. J., Beverloo, H. Berna, Hoeijmakers, Jan H. J., Kanaar, Roland
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
DNA Dynamics and Chromosome Structure
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC480908/
https://ncbi.nlm.nih.gov/pubmed/15199134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.5776-5787.2004
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