The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks

Interstrand cross-links (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer chemotherapy. ICLs covalently tether both strands of duplex DNA, preventing the strand unwinding that is essential for polymerase access. The mechanism of ICL repair in mammalian cel...

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Bibliografiske detaljer
Main Authors: Niedernhofer, Laura J., Odijk, Hanny, Budzowska, Magda, van Drunen, Ellen, Maas, Alex, Theil, Arjan F., de Wit, Jan, Jaspers, N. G. J., Beverloo, H. Berna, Hoeijmakers, Jan H. J., Kanaar, Roland
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC480908/
https://ncbi.nlm.nih.gov/pubmed/15199134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.5776-5787.2004
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