ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

ERCC1-XPF endonuclease is required for nucleotide excision repair (NER) of helix-distorting DNA lesions. However, mutations in ERCC1 or XPF in humans or mice cause a more severe phenotype than absence of NER, prompting a search for novel repair activities of the nuclease. In Saccharomyces cerevisiae...

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Main Authors: Ahmad, Anwaar, Robinson, Andria Rasile, Duensing, Anette, van Drunen, Ellen, Beverloo, H. Berna, Weisberg, David B., Hasty, Paul, Hoeijmakers, Jan H. J., Niedernhofer, Laura J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519706/
https://ncbi.nlm.nih.gov/pubmed/18541667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00293-08
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