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The structure-specific endonuclease Ercc1–Xpf is required for targeted gene replacement in embryonic stem cells

The Ercc1–Xpf heterodimer, a highly conserved structure-specific endonuclease, functions in multiple DNA repair pathways that are pivotal for maintaining genome stability, including nucleotide excision repair, interstrand crosslink repair and homologous recombination. Ercc1–Xpf incises double-strand...

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Udgivet i:EMBO J
Principais autores: Niedernhofer, Laura J., Essers, Jeroen, Weeda, Geert, Beverloo, Berna, de Wit, Jan, Muijtjens, Manja, Odijk, Hanny, Hoeijmakers, Jan H.J., Kanaar, Roland
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125716/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707424/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6540
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