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The structure-specific endonuclease Ercc1–Xpf is required for targeted gene replacement in embryonic stem cells
The Ercc1–Xpf heterodimer, a highly conserved structure-specific endonuclease, functions in multiple DNA repair pathways that are pivotal for maintaining genome stability, including nucleotide excision repair, interstrand crosslink repair and homologous recombination. Ercc1–Xpf incises double-strand...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125716/ https://ncbi.nlm.nih.gov/pubmed/11707424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.22.6540 |
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