RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks

During replication‐coupled DNA interstrand crosslink (ICL) repair, the XPF‐ERCC1 endonuclease is required for the incisions that release, or “unhook”, ICLs, but the mechanism of ICL unhooking remains largely unknown. Incisions are triggered when the nascent leading strand of a replication fork strik...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Abdullah, Ummi B, McGouran, Joanna F, Brolih, Sanja, Ptchelkine, Denis, El‐Sagheer, Afaf H, Brown, Tom, McHugh, Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510000/
https://ncbi.nlm.nih.gov/pubmed/28607004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796664
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