The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks

Interstrand cross-links (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer chemotherapy. ICLs covalently tether both strands of duplex DNA, preventing the strand unwinding that is essential for polymerase access. The mechanism of ICL repair in mammalian cel...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Niedernhofer, Laura J., Odijk, Hanny, Budzowska, Magda, van Drunen, Ellen, Maas, Alex, Theil, Arjan F., de Wit, Jan, Jaspers, N. G. J., Beverloo, H. Berna, Hoeijmakers, Jan H. J., Kanaar, Roland
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2004
Pynciau:
DNA Dynamics and Chromosome Structure
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC480908/
https://ncbi.nlm.nih.gov/pubmed/15199134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.5776-5787.2004
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