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The facial triad in the α-ketoglutarate dependent oxygenase FIH: a role for sterics in linking substrate binding to O(2) activation
The factor inhibiting hypoxia inducible factor-1α (FIH) is a nonheme Fe(II)/αKG oxygenase using a 2-His-1-Asp facial triad. FIH activates O(2) via oxidative decarboxylation of α-ketoglutarate (αKG) to generate an enzyme-based oxidant which hydroxylates the Asn(803) residue within the C-terminal tran...
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| Publicado no: | J Inorg Biochem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5161613/ https://ncbi.nlm.nih.gov/pubmed/27815979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2016.10.007 |
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