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O(2) Activation by Nonheme Fe(II) α-Ketoglutarate Dependent Enzyme Variants: Elucidating the Role of the Facial Triad Carboxylate in FIH.
FIH (Factor Inhibiting HIF [Hypoxia Inducible Factor]) is an α-ketoglutarate (αKG)-dependent non-heme iron enzyme that catalyzes the hydroxylation of the C-terminal transactivation domain (CAD) asparagine residue in HIF-1α to regulate cellular oxygen levels. The role of the facial triad carboxylate...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6146021/ https://ncbi.nlm.nih.gov/pubmed/30148961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b07277 |
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