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Auto-hydroxylation of FIH-1: an Fe(II), α-ketoglutarate-dependent human hypoxia sensor
HIF-asparaginyl hydroxylase (FIH-1) normally couples O(2)-activation to hydroxylation of Asn(803) on the α-subunit of the hypoxia-inducible factor (HIFα), a key step in pO(2) sensing; in the absence of HIFα, O(2)-activation becomes uncoupled, leading to self-hydroxylation at Trp(296) and a purple Fe...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2668816/ https://ncbi.nlm.nih.gov/pubmed/18830487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b809099h |
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