Cargando...
Auto-hydroxylation of FIH-1: an Fe(II), α-ketoglutarate-dependent human hypoxia sensor
HIF-asparaginyl hydroxylase (FIH-1) normally couples O(2)-activation to hydroxylation of Asn(803) on the α-subunit of the hypoxia-inducible factor (HIFα), a key step in pO(2) sensing; in the absence of HIFα, O(2)-activation becomes uncoupled, leading to self-hydroxylation at Trp(296) and a purple Fe...
Gardado en:
| Main Authors: | , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2668816/ https://ncbi.nlm.nih.gov/pubmed/18830487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b809099h |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|