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Auto-hydroxylation of FIH-1: an Fe(II), α-ketoglutarate-dependent human hypoxia sensor

HIF-asparaginyl hydroxylase (FIH-1) normally couples O(2)-activation to hydroxylation of Asn(803) on the α-subunit of the hypoxia-inducible factor (HIFα), a key step in pO(2) sensing; in the absence of HIFα, O(2)-activation becomes uncoupled, leading to self-hydroxylation at Trp(296) and a purple Fe...

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Autori principali: Chen, Yuan-Han, Comeaux, Lindsay M., Eyles, Stephen J., Knapp, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668816/
https://ncbi.nlm.nih.gov/pubmed/18830487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b809099h
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