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Investigations on the role of a solvent tunnel in the α-ketoglutarate dependent oxygenase Factor Inhibiting HIF (FIH)
Non-heme Fe(II)/α-ketoglutarate (αKG)-dependent oxygenases catalyze a wide array of reactions through coupling oxidative decarboxylation of αKG to substrate oxygenation. This class of enzymes follows a sequential mechanism in which O(2) reacts only after binding primary substrate, raising questions...
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| Publicado no: | J Inorg Biochem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5726895/ https://ncbi.nlm.nih.gov/pubmed/29078149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2017.10.001 |
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