The Rate-Limiting Step of O(2) Activation in the α-Ketoglutarate Oxygenase Factor Inhibiting Hypoxia Inducible Factor

[Image: see text] Factor inhibiting HIF (FIH) is a cellular O(2)-sensing enzyme, which hydroxylates the hypoxia inducible factor-1α. Previously reported inverse solvent kinetic isotope effects indicated that FIH limits its overall turnover through an O(2) activation step ( J. A. Hangasky, E. Saban,...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Hangasky, John A., Gandhi, Hasand, Valliere, Meaghan A., Ostrom, Nathaniel E., Knapp, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283935/
https://ncbi.nlm.nih.gov/pubmed/25423620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501246v
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