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Chloride Supports O(2) Activation in the D201G Facial Triad Variant of Factor-Inhibiting Hypoxia Inducible Factor, an α-Ketoglutarate Dependent Oxygenase
α-Ketoglutarate (αKG) dependent oxygenases comprise a large superfamily of enzymes that activate O(2) for varied reactions. While most of these enzymes contain a nonheme Fe bound by a His(2)(Asp/Glu) facial triad, a small number of αKG-dependent halogenases require only the two His ligands to bind F...
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| Publié dans: | Inorg Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6496954/ https://ncbi.nlm.nih.gov/pubmed/30252455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.inorgchem.8b01736 |
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