The facial triad in the α-ketoglutarate dependent oxygenase FIH: a role for sterics in linking substrate binding to O(2) activation

The factor inhibiting hypoxia inducible factor-1α (FIH) is a nonheme Fe(II)/αKG oxygenase using a 2-His-1-Asp facial triad. FIH activates O(2) via oxidative decarboxylation of α-ketoglutarate (αKG) to generate an enzyme-based oxidant which hydroxylates the Asn(803) residue within the C-terminal tran...

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Detaylı Bibliyografya
Yayımlandı:J Inorg Biochem
Asıl Yazarlar: Hangasky, John A., Taabazuing, Cornelius Y., Martin, Cristina B., Eron, Scott J., Knapp, Michael J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161613/
https://ncbi.nlm.nih.gov/pubmed/27815979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2016.10.007
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