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Substrate promotes productive gas binding in the αKG-dependent oxygenase FIH
The Fe(2+)/αKG-dependent oxygenases use molecular oxygen to carry out a wide variety of reactions with important biological implications, such as DNA base-excision repair, histone demethylation, and the cellular hypoxia response. These enzymes follow a sequential mechanism in which O(2) binds and re...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4793777/ https://ncbi.nlm.nih.gov/pubmed/26727884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01003 |
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