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Substrate promotes productive gas binding in the αKG-dependent oxygenase FIH

The Fe(2+)/αKG-dependent oxygenases use molecular oxygen to carry out a wide variety of reactions with important biological implications, such as DNA base-excision repair, histone demethylation, and the cellular hypoxia response. These enzymes follow a sequential mechanism in which O(2) binds and re...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Taabazuing, Cornelius Y., Fermann, Justin, Garman, Scott, Knapp, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793777/
https://ncbi.nlm.nih.gov/pubmed/26727884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01003
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