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Substrate Positioning by Gln(239) Stimulates Turnover in Factor Inhibiting HIF, an αKG-Dependent Hydroxylase
[Image: see text] Nonheme Fe(II)/αKG-dependent oxygenases catalyze diverse reactions, typically inserting an O atom from O(2) into a C–H bond. Although the key to their catalytic cycle is the fact that binding and positioning of primary substrate precede O(2) activation, the means by which substrate...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2014
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4165446/ https://ncbi.nlm.nih.gov/pubmed/25119663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500703s |
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