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The Rate-Limiting Step of O(2) Activation in the α-Ketoglutarate Oxygenase Factor Inhibiting Hypoxia Inducible Factor
[Image: see text] Factor inhibiting HIF (FIH) is a cellular O(2)-sensing enzyme, which hydroxylates the hypoxia inducible factor-1α. Previously reported inverse solvent kinetic isotope effects indicated that FIH limits its overall turnover through an O(2) activation step ( J. A. Hangasky, E. Saban,...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American
Chemical Society
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4283935/ https://ncbi.nlm.nih.gov/pubmed/25423620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501246v |
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