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First- and second-sphere contributions to Fe(II) site activation by cosubstrate binding in nonheme Fe enzymes
Nonheme Fe(II) enzymes exhibit a general mechanistic strategy where binding all cosubstrates opens a coordination site on the Fe(II) for O(2) activation. This study shows that strong-donor ligands, steric interactions with the substrate and second-sphere H-bonding to the facial triad carboxylate all...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976902/ https://ncbi.nlm.nih.gov/pubmed/24292428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3dt53201a |
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