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Spectroscopic Studies of the Mononuclear Nonheme Fe(II) Enzyme FIH: Second–Sphere Contributions to Reactivity

Factor Inhibiting Hypoxia–Inducible Factor (FIH) is an α-ketoglutarate (αKG) dependent enzyme which catalyzes hydroxylation of residue Asn803 in the C-terminal transactivation domain (CAD) of hypoxia–inducible factor 1α (HIF-1α) and plays an important role in cellular oxygen sensing and hypoxic resp...

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Autors principals: Light, Kenneth M., Hangasky, John A., Knapp, Michael J., Solomon, Edward I.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712650/
https://ncbi.nlm.nih.gov/pubmed/23742069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja312571m
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