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Spectroscopic Studies of the Mononuclear Nonheme Fe(II) Enzyme FIH: Second–Sphere Contributions to Reactivity
Factor Inhibiting Hypoxia–Inducible Factor (FIH) is an α-ketoglutarate (αKG) dependent enzyme which catalyzes hydroxylation of residue Asn803 in the C-terminal transactivation domain (CAD) of hypoxia–inducible factor 1α (HIF-1α) and plays an important role in cellular oxygen sensing and hypoxic resp...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712650/ https://ncbi.nlm.nih.gov/pubmed/23742069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja312571m |
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